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Clinical investigation on treatment of Chronic Hepatitis B with Chinese medicine



Clinical investigation on Kidney-Tonifying and Meridian-Reopening Method in Treating Chronic Hepatitis B of Kidney-Deficiency and Blood-Stagnation Syndrome
 
Objective: To observe the clinical effect of "Kidney-Tonifying and Meridian-Reopening" method in the treatment of chronic hepatitis B of kidney-deficiency and blood-stagnation syndrome.
 
Methods: 56 cases of chronic hepatitis B who had all been treated with traditional Chinese and western meditation for over 1 year were selected. Their ALT had been constantly higher than the normal, and the symptoms were not markedly improved. All of them were infected with HBV, among whom 4 were complicated with HDV infection and 1 was with HCV infection. They were divided into the treated group (36 ~) and control coup (20 cases), and their conditions were similar before the treatment. The diagnosis was made in conformity to the Criteria of Diagnosis established in the Fifth National Symposium of Infection and Parasitic Diseases in Beijing, in May of 1995. The diagnosis of Traditional Chinese Medicine was made in reference to “kidney-deficiency and blood-stagnation” syndrome in the criteria of Traditional Chinese syndrome differentiation for viral hepatitis. To the treated group, Scorpio, Centipede, Bombyx Batryticatus, Caulis Polygoni Multiflori, and Cordyceps were taken as the major components in the prescription, while others were combined based on the individual condition i.e. Rhizoma Pinelliae, and pericarpium Citri Reticulatae for the excess of dampness; Flos Lonicerae and Fructus Forsythias for predominance of heat; and Carapax Trionycis and Squama Manitis for remarkable kidney deficiency. The materials were decocted with water, one dose a day, and the prescription was modified every week. One course of treatment consisted of 6 months, usually 2 courses were necessary. Meanwhile other liver-Protecting medicaments could also be administrated. To the control group, “Herba Abri Pill” was medicated. The clinical manifestations, the tongue proper, and the complexion were observed, as well as the lab indexes e.g. ALT, albumin, serum HBV markers, and serum fibrosis markers (HA, PCIII, IV, LN, etc,).
 
Results: (1) ALT: in the treated group there was reduction in 34 cases in various degree. 22 cases were, renormalized after 6 months' medication, 28 cases were renormalized after l-year medication, but there was recurrence 1 month or 2 after the medication stopped. In the control group, 3 cases were renormalized after the treatment for 6 months and 4 were renormalized after 1 year. 1 case recurred 1month or 2 after the treatment was over. There was a noticeable difference of renormalized rate for ALT between the treated and control group, after the treatment for 1 year. (P<0.01); (2) Serum albumin: In the treated group, before the treatment, it had been lower (30g/L-34g/L) than normal in 9 cases but after 6 months 4 restored to normal, And after 1 year 6 cases restored to normal, all over 35g/L; and in the control group, before the treatment, it had been lower (30g/L-34g/L) than normal in 4 cases, and 1 restored to normal 1 year after; (3) tongue proper and complexion: in the treated group. 28 cases had recovery of tongue and complexion from the darkish tongue and dull complexion and at same time their ALT also restored to normal, but the tongue and complexion of the others did not convert remarkably; in the control group, the complexion was quite changeable; (4)Symptoms: before the treatment, the chief complaints were abdominal distention and fatigue, but some patients also complained of poor appetite and nausea and after the treatment, some had improvement of symptoms associated with the conversion of tongue and complexion, but some had only their symptoms improved, and their tongue and complexion were not really converted, so their condition of ALT was quite unstable; (5) Indices of virus: in the treated group, after l-year medication, 3 cases had the negative-conversion of HBeAg, and HBV-DNA, while in the control group, there was only one case; (6) The conversion of serum fibrosis markers: in the treated group, all the four indices i.e. HA,PCIII,PCIV, and LN were markedly reduced after the treatment and statistical processing found very noticeable difference (P<0.01) of HA and noticeable difference (p<0.01) of the other 3; in control group, all the indices were not markedly reduced.
 
Conclusion: This method is apperantly effective in improving the clinical symptoms, liver function, and serum fibrosis indices of chronic hepatitis B of kidney-deficiency and blood-stagnation syndrome.
 
By Yuan Guiyu & Jia Jianwei
 

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