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Clinical and Experimental Study on Therapeutic Effect of Xialian Yiyou capsule


Clinical and Experimental Study on Therapeutic Effect of Xialian Yiyou capsule on Infected Gastritis Caused by HP

Objective: Observation on the therapeutic effect of Xialian Yiyou capsule (inhibition to HP capsule) on infected gastritis caused by HP. Develop and investigate classical prescription systematically.

Methods: Clinical and experimental study on therapy of infected gastritis caused by HP through application of capsules made of Banxia Xiexin Tang (decoction for Purging stomach-fire) and Cortex magnoliae officinalis:

(l) Clinical study: 136 cases in treated group and 90 cases in control group. Stomachoscopy was carried out in all cases. HP positive gastritis was diagnosed by pathological examination and quick urease test. Clinical symptoms observed subjects coincide with "Instruction Principles of Clinical Study on Chinese Drugs and New Drugs" and belong to spleen deficiency and stomach heat type. In treatment group capsule of Xialian Yiyou are used. It composed mainly of Rhizoma pinelliae, Radix scutellariae, Rhizoma coptidis, Radix codonopsis pilosulae, Rhizoma curcumae longae, Cortex magnoliae officinalis, Fructus ziziphi jujubae, Radix glycyrrhizae. In control group capsule of Lizhu Dele (colloidal bismuth subcitrate) was used. 4 weeks as a course and evaluation of the effectiveness made weekly. "Standard in diagnosis, differentiation of symptoms, therapeutic effect evaluation of chronic gastritis by combination of traditional Chinese medicine and western medicine" set up Nov 1989 at Nanchang are referred for evaluation of therapeutic effect;

(2) Experimental study:
 1).Effect of capsule of Xialian Yiyou on rat ulcer model made by ligation of Pylorus. 61 rats are randomly distributed to 6 groups. 11 in model group, 10 each in other 5 groups. The model was made according to the methods in "Collections of Instruction Principle for Pre-clinical Study of New Drugs. Pharmacology". Revised Okabe methods are used as indecies for ulcer evaluation. Ulcer index and ulcer inhibitory rate was calculated; 

2).Anti-inflammation experiment of capsule of Xialian Yiyou: 60 mice were distributed randomly into 6 groups with 6 in each group. Model was made according to the methods in "Guide to Study of Chinese Drugs and New Drugs, Pharmacology". Effect on swollen of ear lobe was observed: 60 rats were distributed to 6 groups randomly with 10 rats in each group. Model was made according to "methodsology in Pharmacological Study of Chinese Drugs". Effect on granulomatous tissue growth by cotton bolus was observed;

3).Analgesic experiment of capsule of Xialian Yiyou: 72 mice distributed randomly to 6 groups with 12 in each group. Inhibitory effect was observed by body twitch methods.

Results: The clinical results demonstrates that as compared with control group, capsule of Xialian Yiyou is better in alleviating clinical symptom, relieving mucosal inflammation and removing HP (p<0.05-0.01). Results from animal experiment show that Xialian Yiyou capsule has significant effect in anti-inflammation, analgesia, evacuation of Stomach and peptic ulcer formation. As compared with the control group the difference is significant (p<0.05-0.01). No bad side effect is found in acute toxicity test.

Conclusion: Therapeutic effect of Xialian Yiyou capsule on inflammatory gastritis caused by HP, is definite. It is safe and non-toxic.

By Ji Aiying, Zhao Wenxia, Wang Zhihui, etc.

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