WORLD
JOURNAL OF ACUPUNCTURE-MOXIBUSTION
Vol.10 No.2,
June, 2000
Short Report
Acupuncture Treatment Can
Prevent Decrease of cAMP and cGMP Contents of the Sciatic Nerve in
the Diabetes Rats
by Wang Xin,
et al
(Institute of
Acupuncture and Moxibustion, China Academy of TCM,
Beijing
100700, China)
Objective:
To observe the effect of acupuncture on cAMP and cGMP contents of
the sciatic nerve in diabetes rats. Methods: 33 Wistar male rats
were randomly divided into normal control group (n=13), diabetes
model group (n=9) and acupuncture +model group (n=12). Rats of the
lateral two groups were injected intraperitoneally with
streptozotoxin (STZ, 60 mg/kg) for establishing diabetes model. 48
hours later, if the blood glucose concentration was higher than
16.7 mmol/L, the diabetes model was considered as success. In
acupuncture +model group, “Sanyinjia o" (SP 6),
“Shenshu" (BL 23) and Zusanli (ST 36) were punctured and
stimulated with an electroacupuncture therapeutic apparatus for 20
min, once every other day. After 3 months' treatment, the sciatic
nerve samples of the 3 groups were taken out for cAMP and cGMP
detection. Results: In comparison with the normal control group,
the concentration of cAMP and cGMP in the sciatic nerve of the
diabetes mod el group was significantly lower (P<0.01). While
there was no significant difference between acupuncture + model
group and normal control group in cAMP and cGMP contents,
suggesting an up-regulation action of acupuncture on sciatic nerve
c A MP and cGMP level in diabetes rats. Conclusion: Acupuncture
treatment could prevent the decrease of cAMP and cGMP level of
sciatic nerve in diabetes rats.
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